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Survodutide Dosing The SYNCHRONIZE Phase 3 trials use a modified escalation protocol designed to improve tolerability compared to Phase 2: Starting dose: Low dose with gradual increases Escalation: Extended titration period with flexibility Target doses: 3.6mg or 6.0mg weekly (SYNCHRONIZE-1) Pause option: Ability to temporarily stop dosing for GI symptoms Time to maintenance: Extended to reduce side effects The inclusion of a pause option in Survodutide trials reflects lessons learned from Phase 2 about the importance of allowing patient-directed tolerance management

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Subsequent increases of 2.5 mg occur every four weeks as tolerated, up to a maximum of 15 mg per week

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