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Side Effects to Know About The most common side effects are digestive: Nausea & Vomiting Diarrhea or constipation Bloating These often improve after the first few weeks as your body adjusts

These rare side effects include an increased heart rate, low blood sugar, gallbladder issues, and pancreatitis

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After an oral glucose load or a meal, this DPP-4 inhibition resulted in a 2- to 3-fold increase in circulating levels of active GLP-1 and GIP, decreased glucagon concentrations, and increased responsiveness of insulin release to glucose, resulting in higher C-peptide and insulin concentrations