glp 1 agonist liraglutide Compounded Study shows liraglutide results in

In a recent study, administration of exendin-4, a long-acting GLP-1RA, stimulated -cell proliferation in juvenile human islets by inducing gene expressions of calcineurin/nuclear factor of activated T cells (NFAT) signaling, a proliferating factor such as NFATC1, and a cell cycle regulator such as cyclin A1 [57]

Highlights Glucagon-like peptide-1 (GLP-1) is a 30-amino acid peptide hormone produced by intestinal L cells through differential processing of the proglucagon (PG) gene [1]

A defining pharmacologic feature of these agents is prolonged receptor occupancy, which distinguishes therapeutic GLP-1R signaling from its endogenous, pulsatile counterpart

Photograph of Professor Goodman, credit: Goodman

Saisho Y

A multi-species model study, this time using the GLP-1RA liraglutide, did not demonstrate adverse pancreatic effects, including cell proliferation 29