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The science behind GLP-1 and immune function GLP-1 receptors are everywhere

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Tirzepatide (Zepbound) has received recent FDA approval for chronic weight management alongside GLP-1 receptor agonist liraglutide (Saxenda) and semaglutide (Wegovy), following the demonstration of over 20% mean weight loss achieved in non-diabetic patients with obesity [105110]

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Enrichment analysis Enrichment analysis of genes was done using the API for EnrichR database ( by implementing Hypergeometric test with Benjamini and Hochberg correction, while the reference was the human genome

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Am J Physiol Gastrointest Liver Physiol 2006;290:G852-G858

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Indeed, -defensin reduces the abundance of SFB, belonging to the phylum Firmicutes, and decreases the numbers of Th17 cells producing IL-17 in the lamina propria [32]

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It affects portions, hunger, fullness, and metabolic signaling

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