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In particular, in both studies, liraglutide 1.8 mg/day induced a significant increase in SHBG and a decrease in free testosterone

The company is evaluating another key candidate, triple-acting incretin, retatrutide (which combines GLP-1, GIP and glucagon), in type II diabetes and obesity, along with other indications like obstructive sleep apnea, knee osteoarthritis and chronic low back pain, in late-stage studies

Informed consent: Informed consent was obtained from all individuals included in this study

Two members of the writing group, one from the ADA and one from the EASD, were assigned to be the primary authors of each section

The glucagon receptor activation drives hepatic fat oxidation in ways that dual agonists do not replicate

Internet J Endocrinol