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Importantly, pooled analyses from these trials did not demonstrate a statistically significant increase in pancreatic cancer incidence among GLP-1 users compared with placebo

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Each rat underwent an 18-day cycle during which they received the assigned injection every other daytotaling 8 injections over 15 daysto simulate once-weekly administration in human patients (Geisler 2022)

Injecting a solution with particles can cause irritation at the injection site or, more seriously, a blockage in the needle or a negative systemic reaction