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Toplak, H., Auer, M., Ziegler, O., Marterer, N., Handl, S., & Ludvik, B
Oxidative stress, a key mediator of cardiovascular damage in diabetes and obesity, is significantly attenuated by GLP-1 agonists through multiple mechanisms [32]
doi: 10.3390/ijms25094580 56
"As we look to build an impactful portfolio of medicines to address patient needs, our data presented at ADA 2025 demonstrates not only how we are already delivering for a wide range of these needs with semaglutide, but that we are continuing to invest in innovation to support people living with serious chronic disease." The presentation of the CagriSema REDEFINE 1 and 2 trials are the first ever Phase 3 data presented on a GLP-1 and amylin receptor agonist combination, offering insights into the potential of this investigational medicine
Both formulations activate the same GLP-1 receptors and follow the same appetite-control timeline
Obesity (Silver Spring) 2014;22(1):110118
