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Description
Short-acting drugs primarily lower postprandial blood glucose levels by slowing gastric emptying, while long-acting GLP-1 RAs are more effective at reducing fasting blood glucose levels, mainly by promoting insulin secretion and inhibiting glucagon release

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comparing liraglutide 1.2 mg/day + metformin 1000 mg BID with liraglutide 3 mg/day, the combination therapy was effective in reducing fasting glucose and insulin, HOMA-IR, and LDL cholesterol, while only the high dose of liraglutide resulted in a significant improvement of 120 min during OGTT glucose and insulin levels along with a higher weight loss [63]

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Anyone who needs a GLP-1 medication for treatment of diabetes or weight management should not use a patch in place of the real prescription medication. How Much Should I Expect to Pay for Mounjaro (Tirzepatide)
