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Constipation: Ensure adequate fiber and hydration alongside protein intake
The efficacy of these therapies is related to the activation of GLP-1 receptor (GLP-1R), which is widely expressed in several tissues
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Increase the dose gradually as prescribed, eat smaller meals, avoid greasy foods, eat slowly and stay well hydrated

The risk of renal adverse reactions with WEGOVY was increased in adult patients with a history of renal impairment (trials included 65 patients with a history of moderate or severe renal impairment at baseline), and occurred more frequently during dose titration