mechanism of action of glp 1 agonists GLP-1 Receptor as Treatments for Type 2 Diabetes GLP-1 receptor agonists (GLP-1RAs): cardiovascular

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10.1136/bmj.q1645 [DOI] [PubMed] [Google Scholar] 10.Gulak MA, Murphy P

Activation of GLP-1R has been associated with the induction of antioxidant enzymes, such as superoxide dismutase ( SOD ) and catalase, which are involved in the neutralization of ROS [87]

These medications are particularly beneficial for those who may not be candidates for surgery or prefer a less invasive approach

Finally, another layer of complexity is added when considering the evidence of a leaky bloodbrain barrier across several neuropsychiatric disorders 255 , which could further increase the brain penetrance of GLP-1RAs administered to people with such illnesses