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Heartburn happens when stomach acid moves up into the esophagus, causing a burning feeling in the chest

Figure: Age-adjusted trends in overweight, obesity, and severe obesity among men and women aged 2074: United States, 19601962 through 20172018, CDC Its also very difficult for people who are already obese to sustain significant weight loss, as the body fights very hard to retain fat through its regulatory processes

Signs of an allergic reaction include dizziness , fast heartbeat , hives/itching, swelling of the face , tongue or lips and difficulty breathing or swallowing

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The involvement of melatonin is dose-dependent, and if at physiological concentrations, it inhibited NMDA-induced current
