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(65) demonstrated that intraperitoneal rather than intravenous administration, which more accurately mimics the endogenous route of action of GLP-1, requires intact vagal afferent fibers to induce satiation

However, discontinuation often leads to weight regain and loss of cardiometabolic benefits, 42 , 87 suggesting that, as with traditional antihypertensive drugs, sustained BP control may require ongoing use

Cell Metabolism 27450460.e6

Amylinergic control of food intake in lean and obese rodents

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Adult Obesity Facts.