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doi:10.1038/nature22378

Emerging Pharmacotherapies for Obesity: A Systematic Review
ACS Omega

A patient who can afford and tolerate semaglutide for two years will have better outcomes than a patient who starts tirzepatide, hits financial or side effect barriers at month four, and discontinues
224 Physiological properties of the body, including organ mass and volume, blood flow rate, plasma protein levels, and the abundance of enzyme and transporter expression, are mathematically described within the model

Theyll likely need to adapt pricing, marketing, and real-world evidence strategies to continue pushing payers toward coverage
