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427,428,429 The compound NLY01 is particularly effective at attenuating the activity of proinflammatory microglia and preventing the transformation of astrocytes to a reactive phenotype

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Glucagon-like peptide 1 (GLP1) receptor (GLP1R) agonists reduce body weight, glycaemia, blood pressure, postprandial lipaemia and inflammation actions that could contribute to the reduction of cardiovascular events

GLP-1 receptor agonists enhance beneficial bacterial strains, including Bifidobacterium and Lactobacillus, while diminishing harmful species such as Clostridium and Enterobacteriaceae (Singh et al

This prevents the common mistake of attributing weight changes to medication effects when they actually result from dietary shifts during transitions

These metabolic benefits have been translated from mice to nonhuman primates and humans
