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Safety and efficacy of oral semaglutide versus dulaglutide in Japanese patients with type 2 diabetes (PIONEER 10): An open-label, randomised, active-controlled, phase 3a trial

KD also has short-term adverse effects that have been termed 'keto flu, including symptoms of dizziness, constipation, nausea, fatigue, and headaches as the body adjusts to ketosis

Closely follow RYBELSUS administration instructions when coadministering with other oral medications and consider increased monitoring for medications with a narrow therapeutic index, such as levothyroxine Use in Specific Populations Pregnancy: Available data with RYBELSUS are not sufficient to determine a drug associated risk for major birth defects, miscarriage, or other adverse maternal or fetal outcomes

doi: 10.1016/j.numecd.2007.12.005

Kepp KP, Sensi SL, Johnsen KB, Barrio JR, Hoilund-Carlsen PF, Neve RL, et al

PMCID: PMC6971782