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Retatrutide is an investigational triple hormone receptor agonist that simultaneously targets three receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors

The concept of microdosing with GLP-1 agonists describes a treatment strategy in which only a fraction of the usual therapeutic dose, typically 5% to 25%, is administered, often via individually compounded prescriptions and at longer intervals

The result is lower fasting glucose, lower post-meal glucose spikes, and lower HbA1c over time

Same-day virtual appointments and physician-guided GLP-1 weight-loss care from home

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It would be desirable to develop a version of these drugs that specifically targets pericyte-mediated reduction of coronary blood flow, for use in cases of coronary ischaemia