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Among the subcutaneous GLP-1 receptor agonists, some are dosed once daily (liraglutide and lixisenatide) or twice daily (exenatide), whereas others are given once weekly (dulaglutide, semaglutide, and exenatide extended release) (813)

Lillys tirzepatide (Mounjaro and Zepbound) is similarly a modified and stabilised form of the related glucose-dependent insulinotropic polypeptide (GIP) hormone

Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

Almost 95% of people who take GLP-1 drugs do not have negative effects, making side effects relatively rare

Sharing her approach to Today, she said: "A misconception is that it's a shortcut

Additional information on the synthesis of the GLP-1 analogues and their characterizations is available in the Supplementary data (Supplementary Methods and Supplementary Figs