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et al., The increasing rate of diabetes in Pakistan: A silent killer (2022) IDF, Prevalence of Diabetes in Pakistan (2024) Jastreboff et al., NEJM, Phase 2 obesity trial of retatrutide (2023) Reuters Next generation Lilly weight-loss drug shows added heart, liver benefits (2024) Investopedia / news20 Eli Lilly shares rise after drug helps patients lose more weight than competitors (2023) Lancet Phase 2 trial on T2DM (via ResearchGate summary) PMC meta-analysis: weight/metabolic outcomes of retatrutide Anti-obesity medication (retatrutide entry) News21 (Axios) Extraordinary promise of retatrutide (2023) USA Today (American Diabetes Association summary) News25 (NY Post) re: Phase 3 status and side effects

Outlook for obesity in 2025 Looking ahead to 2025, a number of key events will shape the future direction of the AOM market: Obesity definition : The Lancet Commission on Diagnostic Criteria of Clinical Obesity is expected to report its recommendations in early 2025

FDA specifically lists BPC-157 among bulk drug substances that raise compounding safety-risk concerns, so it should not be discussed as though it were interchangeable with liraglutide

Under some plans, the average monthly cost of Mounjaro nearly doubled from 2024 to 2025, from $99 to $196

The same holds for the newest drugs in the pipeline, including CagriSema, retatrutide and the Chinese-developed mazdutide, whose weight-loss numbers rival tirzepatides but whose long-term risk data is not yet in