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But human observational evidence is increasingly reassuring on major malformations when confounding is handled carefullyfor example, large datasets show no substantial increased risk of major congenital malformations with early exposure, and a European teratology cohort reported no increase in major birth defects vs diabetes/high-BMI comparators

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While overall risk of macular degeneration remained low, a study suggests that GLP-1 drugs may have increased that risk in people with diabetes.

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