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GLP-1RAs such as liraglutide and exenatide decrease pro-inflammatory cytokines, tumor necrosis factor-alpha ( TNF- ), and interleukin-1 (IL-18) in rodent mouse models of diabetic neuropathy [69,70]
1822 Given that endogenous hyperinsulinemia is one of the proposed factors for the link between cancer and obesity and DM, an improved understanding of the impact of insulin therapy on cancer risk and progression is imperative
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