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Multiple studies demonstrate that the GLP1 receptor antagonist exendin 939 reduces peak postprandial circulating levels of insulin and raises the glucose nadir 126,137

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However, there are reasons to be cautiously optimistic about retatrutide cardiovascular effects

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41 As discussed above, mitochondrial dysfunction (mitochondrial bioenergetics, calcium buffering) and mitochondrial quality control systems (mitochondrial dynamics, mitophagy, mitochondrial biogenesis) may be involved in the pathological mechanisms of diabetes-related NDs

So this is the opportunity were talking about for our industry to capitalize on this phenomenon.