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GLP-1R Agonist Evolution: From Diabetes to Weight Loss | Peptidic GLP-1R agonists have received significant media coverage over the past year for their astounding efficacy in several indications

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Purpose of Review This review will summarize the most contemporary trials for glucagon-like peptide 1 receptor agonists (GLP1-RA) and sodium-glucose cotransporter 2 inhibitors (SGLT2-i) and present guidance on management and recommendations on adjunctive tapering of insulin in patients with insulin-dependent diabetes mellitus, which we term de-insulinization. Recent Findings GLP1-RA and SGLT2-i are the principal classes of diabetes medications evidencing cardiovascular benefit

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TRANSCEND-T2D-1: Retatrutide in adults with obesity and type 2 diabetes