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Chronic use of NSAIDs with spironolactone can contribute to fluid retention and exacerbate hypertension

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When used as part of a medical weight loss program, it may make healthy eating habits easier to follow

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Additionally, eating smaller, more frequent meals and ensuring adequate dietary fiber may help ease bloating, nausea and constipation. These side effects are not necessarily a sign that there are major changes in the microbiome, but it is possible, adds Dr