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Rosenstock J, Frias J, Jastreboff AM, Du Y, Lou J, Gurbuz S, Thomas MK, Hartman ML, Haupt A, Milicevic Z, et al

D.YilmazY.Wai-Sun WongV.Adithya LesmanaC

Millions of people are searching for ways to reduce hunger and manage cravings naturally

These compound-specific effects could affect the way in which individual DPP4i are used therapeutically and potentially explain off-target adverse effects, such as hospitalization for heart failure, which is seen only with one DPP4i

doi: 10.1093/jn/nxab029

Results indicate that DA-JC1 reduces neuroinflammation by inhibiting the proliferation of astrocytes and microglia in the substantia nigra, and mitigates the damage of toxic substances MPTP to midbrain dopaminergic neurons and fibers by promoting the expression of BDNF, phosphorylation of Akt in the PI3K/Akt signaling pathway, downregulating the pro-apoptotic protein Bax, and upregulating the anti-apoptotic protein Bcl2 (109, 110)