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Presumably, these diagnoses were all determined by clinical judgment
It is important to note that randomized trials typically involve a highly selective group of individuals who do not accurately reflect the general population with T2DM

Clinical decisions should therefore remain individualized, and continued long-term surveillance is warranted
30 In terms of cardiovascular safety, oral semaglutide was shown to be noninferior to placebo in the PIONEER 6 trial

The precise mechanism of kidney-protective effects of GLP-1 RAs still remains elusive, but likely include direct kidney actions such as inducing natriuresis through NHE3 inhibition in the proximal tubules, suppressing the intrarenal renin-angiotensin system, ameliorating kidney ischemia/hypoxia [63, 64]

Exactly.) Shape Does It Cancel Out the Medication
