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HAMI3379, a small molecule with GPR17 antagonist properties [40], significantly attenuated the MDL29,951-mediated inhibition of F/I-stimulated GLP-1 secretion, shifting the IC 50 of MDL29,951 to 3600 nM (pIC 50 = 5.450.47) (Figure 3D)

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Expert anesthesiologist provides guidance for perioperative care of patients on GLP-1RA therapy