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The crystal structure of ligand coupled to GLP-1R and GIPR extracellular domain (19-21), structure-activity relationships of incretins (10, 24, 25), the similarities in their primary sequences as well as the sequence differences in the middle and the C terminal region of the respective agonists, guided us to rationally design the hybrid peptide with potent GLP-1R and GIPR dual activity in a single molecule

Key Highlights: 48 PSGs for products with no approved ANDAs (25 complex products) 39 PSGs for complex products (6 new, 33 revised) Therapies for COPD, opioid overdose, type 2 diabetes, major depressive disorder, and more Notable PSGs: Ensifentrine inhalation suspension (COPD, RLD: OHTUVAYRE) Naloxone hydrochloride nasal spray (Opioid overdose, RLD: REZENOPY) Semaglutide oral tablet (Type 2 diabetes, RLD: RYBELSUS) Trazodone hydrochloride ER oral tablet (MDD, RLD: OLEPTRO) Link : By publishing PSGs, FDA continues to promote innovation in generic development while advancing public health and patient access to cost-effective medicines

Biotechnology companies are subject to increased governmental regulation which may delay or inhibit the release of new products

Many doctors commonly prescribe medications for off-label uses, or purposes other than what the FDA has explicitly approved them for

Although Mounjaro was launched in the UK as an obesity treatment in February 2024, it was not initially included in the NHS, which is funded through government budgets and taxpayer money

This can make lines and wrinkles look more pronounced, and even result in a saggy, crepey look