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McLean BA, Wong CK, Kaur KD, Seeley RJ, Drucker DJ

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For those who do have access to GLP-1s, utilizing a lifestyle change program staffed with clinicians with expertise in the medications could help address some of the issues raised by those who choose to discontinue their treatment

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Published human pharmacology studies are cited in the research literature

GLP-1Rmediated transport occurs through circumventricular organs (CVOs) and maybe other parts of the hypothalamus via fenestrated capillaries and is partially dependent on tanycytemediated transport through certain localized compartments of the cerebrospinal fluid (CSF)