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GIP and GLP-1 may exert long-term effects on -cell survival and proliferation, potentially delaying the development of and even reversing T2DM

Inflamm Bowel Dis 2024 Nov 27 [Epub]

The incretin effect was estimated to account for approximately 50% - 70% of the postprandial insulin responses in healthy individuals and may be substantially reduced to 20% 30% in individuals with type 2 diabetes mellitus (T2DM) (6, 7), a complex disorder arising from inadequate compensation of insulin secretion by pancreas to counter peripheral insulin resistance

Ther Adv Chronic Dis (2016) 7:417

Activation of its receptor by GLP-1 can promote the phosphorylation of CREB, subsequently fostering the expression of genes related to neuronal survival and regeneration

In this study, 475 patients were randomized