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Slow titration, 4 weeks minimum at each step, dramatically reduces GI burden

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Ravi Somayazula recommends that patients wait until their weight has remained stable for at least three to six months before scheduling surgery

This approach supports both safety and adherence by reducing the likelihood of intolerable side effects that lead to treatment discontinuation

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Besides, KKAy mice were selected and divided into the Lira group and the HF feeding group