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These results provide the hope of effective targeted pharmacology for these patients
It promotes weight loss through multiple mechanisms: reducing appetite and food intake via central nervous system effects, slowing gastric emptying, and improving glycemic control through glucose-dependent insulin secretion [1] [3]
The weight regain isn't simply about eating more
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The transition should include a washout period of at least 1-2 weeks after the last cagrilintide injection, followed by starting the retatrutide titration from the beginning (1 mg weekly)
The good news is that most patients report nausea diminishes significantly within 4 to 8 weeks as their body adapts to the medication
