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Gastroenterology 143 , 913.e7916.e7 (2012)

While these medications don't selectively target belly fat, clinical trials demonstrate meaningful decreases in visceral adipose tissuethe metabolically harmful fat surrounding internal organsas part of overall fat loss

In line with this observation, the combination of LepAB with low-dose liraglutide significantly potentiated the effects of low-dose liraglutide on total body weight and weight loss calculated based on percentage and net loss (in grams)

In particular, they target areas that are important for homeostatic feeding, such as the hypothalamus, and for hedonic responses, such as the nucleus accumbens (NAc), ventral tegmental area (VTA), and laterodorsal tegmental area (LDTg) (Alhadeff et al., 2012

Tryptophan-related metabolites, including kynurenate, xanthurenate, and serotonin, were reduced 2- to 10-fold in PBH in the fasting state