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These substances work through entirely different mechanisms and do not directly interfere with each other's pharmacological actions

It can interact with several medicines, increasing the risk of side effects, particularly gastrointestinal bleeding

When the components of the primary outcome were examined separately, GLP1 RA use was associated with an increased risk of both a new depression diagnosis (HR 1.12

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And the blood sugar concerns are neutralized by the concurrent GLP-1 and GIP activity

iScience 24 , 116 (2021)