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Men with a history of pancreatitis or thyroid cancer

00:02:33 Steve Small: Delayed stomach emptying effect can be helpful here, since it can make patients feel fuller, faster, and eat less overall

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investigated the effects of GLP-1 RAs on [H 3 ]D-aspartate release in purified synaptosomes.Reference Rebosio, Balbi, Passalacqua, Ricciarelli and Fedele 43 Notably, KCl-induced depolarization was potentiated with GLP-1 RA treatment wherein there was a 37% and 43% increase in [H 3 ]D-aspartate release in the cortical and hippocampal synaptosomes, respectively.Reference Rebosio, Balbi, Passalacqua, Ricciarelli and Fedele 43 Administration of exendin-3, a GLP-1 receptor antagonist, and 2-5-dideoxyadenosine both inhibited the observed increased in [H 3 ]D-aspartate, suggesting that activation of GLP-1 receptors is associated with increased glutamatergic signaling