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For patients looking for more convenience, a pen-device version is also dropping next month (April 2026) starting at 4,000/month

Relevant reviews, cohort studies, meta-analyses and randomized controlled trials (RCTs) were reviewed

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The added upregulation of GIP in dual-acting and triple-acting agonists, such as tirzepatide and retatrutide, respectively, resulted in greater reductions in weight loss and insulin sensitivity when compared to medications that acted at the GLP-1 receptor alone

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