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The association between glucagonlike peptide1 receptor agonists (GLP1 RAs) and depression remains uncertain due to contradictory evidence

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PSCs were isolated from male Wistar rats

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In islet alpha cells, GLP-1(936) led to inhibition of Ca2+ entry via voltage-gated Ca2+ channels sensitive to -agatoxin, with consequential pertussis-toxin-sensitive depletion of the docked pool of secretory granules, effects that were prevented by the glucagon receptor antagonists REMD2.59 and L-168049