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In comparison, studies using ezetimibe 10 have shown a 6-7% relative risk reduction and PCSK9 inhibitors 11 ~15% risk reduction for LDL reduction
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Specifically, it suppressed proinflammatory cytokines (TNF-, IL-6), enhanced endogenous antioxidant defenses (SOD), and activated autophagy (LC3), suggesting a potential to modulate the clearance of dysfunctional proteins

Melatonin attenuates antipsychotic metabolic effects: an eight-week randomized, double-blind, parallel-group, placebo-controlled clinical trial

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