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[PMID: 37940910]

Consistent with CD-1 mouse PK data, intact AMG 133 has a shorter mean t 1/2,z compared to total AMG 133 (207 h versus 292 h)

[DOI] [PubMed] [Google Scholar] 95.Zhang Q., Wu Y., Fei X

This rapid glucose lowering can also induce hypoxia, which may modulate the effect of GLP-1 RAs on retinal VEGF expression [100]

Recent research has revealed that under specific circumstances, lactic acid can even become the dominant supplier of pyruvate for the heart, highlighting its importance (44)

What is more, no clear trend for a change in pharmacokinetics was evident across groups with increasing renal dysfunction 12 that allowed us to administer the same dose of the drug and the same blood sampling time points in patients with different degree of renal impairment who were included in our study