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10.1016/S2213-8587(18)30372-3 29 HammanJ

The starting dose is 2mg administered once weekly by subcutaneous injection
Weekly losses of 1 to 2 pounds become common rather than the 3 to 4 pounds seen earlier

Successful murine studies have shown that triagonists, in comparison to dual-incretin co-agonists, more effectively reduced adipose tissue, hepatic steatosis, plasma cholesterol and improved glucose tolerance while achieving a favourable energy balance by increasing energy expenditure and decreasing food intake [91, 92]

Sleep disruption directly attributable to nausea may require addressing nausea management first

Bigger pressures in the U.S
