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In PC12 cells, GLP-1 stimulation of neurite outgrowth is only partially silenced by treatment with the PKA inhibitor H89, indicating that cAMP-mediated activation of PI3K and ERK following GLP-1R agonism does not fully depend on PKA signaling, at least in these cells [825,827]

Sehgal NK et al

This has led to increased interest in whether medications like Wegovy might offer additional support for weight loss in this patient population, whilst raising important questions about safety and potential interactions with thyroid function

Thus, conjugate estradiol delivery differs significantly from peripheral administration of estradiol as in HRT for example

X.WeiJ.et al (2023)