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[DOI] [PubMed] [Google Scholar] 65.Willms B, Werner J, Holst JJ, Orskov C, Creutzfeldt W, Nauck MA

This study included randomized clinical trials that evaluated the cardiometabolic effectiveness and safety of the combination therapy of SGLT-2i and GLP-1RAs versus monotherapy with either SGLT-2i, GLP-1RA, or treatment as usual (TAU) in adults ( 18 years) with T2DM

These results remain significant when controlling for comorbidities such as T2DM

Multiple analyses have demonstrated significant reductions in LDL cholesterol, while Yaping et al