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Proton pump inhibitors (omeprazole, esomeprazole, lansoprazole)

Guaranteed medication availability
This means melatonin does not significantly alter semaglutide blood levels, and semaglutide does not inhibit melatonin clearance

December 19, 2025

For these reasons and more, there has been a massive increase in glucagon-like peptide 1 (GLP-1) agonist use for weight and obesity management

And, like most medications, semaglutide is not a cure
