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Description
Studies have shown that GLP-1 treatment significantly increases the expression levels of BTG2, Pdx1, and the insulin gene in pancreatic cells, indicating that GLP-1 positively regulates insulin gene expression through BTG2, thereby promoting insulin synthesis ( 4.2 Promotion of insulin secretion GLP-1 stimulates insulin secretion in a glucose-dependent manner through specific receptors expressed on pancreatic cells.GLP-1R is a family of secretins (class B) that couples GLP-1 to downstream cell responses, and conformational changes in the receptor upon ligand binding facilitate the interaction between its intracellular region and signaling proteins (Lamont et al., 2012)

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These medications work by stimulating insulin release only when necessary and suppressing glucagon, which helps prevent blood sugar swings and episodes of hypoglycemia
Semaglutide is used to treat conditions such as type 2 diabetes and obesity

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T/GDCA, T/glycodeoxycholic acid
