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Intentional weight loss in overweight and obese patients with knee osteoarthritis: is more better

Among patients with a prior history of CUD, semaglutide was associated with a significantly lower risk for recurrent CUD diagnosis (medical encounters for CUD diagnosis) compared with non-GLP-1RA anti-obesity medications for a 12-month follow-up period (13.0% vs
2025 Aug 4;12(8):e01789

In a Phase 2 NEJM-published trial (2023, n=338, 48 weeks), retatrutide at the highest dose produced mean body weight reduction of approximately 24% in adults with obesity