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Dapagliflozin for small nerve fibre regeneration in diabetic peripheral neuropathy: a randomised controlled study (DINE)

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It has gained attention as a low-calorie sweetener that has minimal effects on blood glucose levels in most studies, making it of potential interest in diabetes management and weight control strategies

More specifically speaking, GLP-1 receptor activation facilitates the presynaptic release of GABA into RGCs via the Gs/cAMP/PKA/Phospholipase C (PLC)/IP3/Ca2+/CaM signaling pathway, ultimately increasing the GABAergic miniature inhibitory postsynaptic currents (m-IPSCs) frequency and contrast sensitivity (Shao et al., 2024)