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In type 2 diabetes, the incretin effect diminishes because of impaired GLP-1 secretion and decreased GIP activity

The EMA has asked Novo Nordisk, which manufactures Ozempic, to add NAION to the list of side effects that can occur with very rare frequency. However, the US label for Ozempic does not contain this side effect

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Researchers suggest these drugs might be toxic to the kidneys when combined with other medications such as non-steroidal anti-inflammatories for pain relief

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Vosoughi K, Atieh J, Khanna L, Khoshbin K, Prokop LJ, Davitkov P, et al