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Description
Lilly also sponsored separate trials to test retatrutide on people with type 2 diabetes

You might feel jittery, have trouble sleeping, or get dry mouth

Identify class and individual glycemic effects of DPP-4 inhibitors in the treatment of type 2 diabetes

Contact your healthcare provider promptly if you experience: Severe or persistent heartburn unresponsive to over-the-counter antacids or lifestyle modifications Difficulty swallowing (dysphagia) or painful swallowing (odynophagia), which may indicate esophageal inflammation or stricture Persistent nausea and vomiting that prevents adequate oral intake or leads to dehydration Vomiting blood (hematemesis) or material resembling coffee grounds Black, tarry stools (melena) or visible blood in stool Severe abdominal pain, particularly if localized to the upper abdomen or radiating to the back (stop medication immediately if pancreatitis is suspected) Right upper quadrant pain, fever, or yellowing of skin/eyes, which may indicate gallbladder disease Unintentional weight loss beyond expected therapeutic effects New or worsening chest pain (call 911 if concerning for heart attack), especially if accompanied by shortness of breath These symptoms may indicate complications such as erosive esophagitis, gastrointestinal bleeding, pancreatitis, or gastroparesis

The results also showed that exenatide treatment was likely to prevent fractures in treated T2DM patients compared with placebo or other anti-hyperglycemic drugs (Zhang et al., 2018)
Across the combined VENTURE study arms, the weekly rate of nausea did not exceed 5% at any point after the first week of treatment
