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Current Status of MOTS-c Research (2026) As of 2026, MOTS-c remains an investigational compound

There were 1.6 million users in England, Scotland and Wales between early 2024 and early 2025, twice as many women as men, typically people aged 45 to 55, according to a study by UCL researchers

The typical adult dose is 250500 mg twice daily, though it should always be taken at the lowest effective dose for the shortest duration necessary, following prescriber guidance

Focus on eating enough to support milk productionaround 400 to 500 extra calories per dayand aim for steady progress rather than quick fixes

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Phase 3 trials have now initiated for overweight and obesity at this point, assessing CagriSema in larger numbers and for longer periods of time. References: Frias JP, et al