giving yourself a semaglutide shot How to give tirzepatide or GLP1 (SubQ) injection! How to Inject Semaglutide for

The demand for a Type 2 diabetes drug continues after being popularized on social media for its off-label use for weight loss.

El uso de agonistas del receptor del pptido similar al glucagn tipo 1 (GLP-1RAs, por sus siglas en ingls), utilizados para tratar la diabetes y la obesidad, podra estar asociado con un amplio espectro de efectos sobre la salud, tanto positivos como un menor riesgo de trastornos cardiometablicos como negativos un mayor riesgo de afecciones gastrointestinales o hipertensin

On August 28, 2024, Eli Lilly and Company submitted anominationto request that its GLP-1 product, tirzepatide, be added to FDAs Demonstrable Difficulties for Compounding (DDC) lists.

GI side effects were the most common adverse events

Others * Long-term metformin use * Proton pump inhibitors (reduce acid absorption) Pathophysiology * Impaired DNA synthesis megaloblastic anemia * Accumulation of methylmalonic acid nerve damage Clinical features Hematological * Fatigue, pallor * Shortness of breath * Megaloblastic anemia Neurological (key distinguishing feature) * Peripheral neuropathy (tingling, numbness) * Loss of vibration and position sense * Ataxia (unsteady gait) * Cognitive changes Severe untreated cases irreversible nerve damage Others * Glossitis (smooth, beefy red tongue) * Mild jaundice Investigations * Serum vitamin B12 * CBC macrocytic anemia ( MCV) * Blood film hypersegmented neutrophils * methylmalonic acid (specific for B12 deficiency) * homocysteine Differentiate from folate deficiency * Both megaloblastic anemia * Only B12 neurological symptoms Management Replacement therapy * Hydroxocobalamin (preferred IM) * Frequent doses initially, then maintenance * Oral B12 if mild and absorption intact Important rule Never give folate alone if B12 deficiency is possible may worsen neurological damage Prevention * Adequate diet (meat, eggs, dairy) * Supplementation in vegans * Monitor high-risk patients (elderly, post-surgery)

Formulated to help maintain healthy metabolic balance, complementing your weight management goals when paired with a balanced diet and regular exercise