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10.1038/s41586-021-03362-0 61 PortincasaP.KhalilM.MahdiL.PerniolaV.IdoneV.GrazianiA.et al (2024)

Currently, three of the incretin-based products are FDA approved for weight loss Wegovy (semaglutide), Saxenda (liraglutide), and Zepbound (tirzepatide)

People With Specific Medical Conditions If you have a history of pancreatitis, gallbladder disease, severe gastroparesis (delayed stomach emptying), medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2), discuss these conditions with your doctor

Baker PD, Morzorati SL, Ellett ML

In 1997, doctors from the Mayo Clinic published findings that demonstrated that the popular combination increased patients risk of heart valve disease and fenfluramine, the culpable substance, was withdrawn soon thereafter (3)